what is ldn

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LDN is derived from an Active Pharmaceutical Drug called Naltrexone. 

Since 1984, Naltrexone, which is commonly used at daily doses of 50-300mg since it was first licensed in 1984 has been used to help treat opiod addictions.

In 1985,  Dr. Bernard Bihari had a groundbreaking clinical trial studying the immune response in HIV/AIDS patients in which he discovered that very low doses of naltrexone (LDN) boosts the weakened immune system.

Since then, researchers have found that at low doses of naltrexone of 1.5 – 4.5 mg, LDN can have beneficial effects on the immune system & pain.  It has been shown to benefit a number of different chronic diseases, including autoimmune diseases and cancer.

LDN works with your immune system through its interactions with your body’s endorphins.  Although endorphins affect your mood, they also play a large role in pain relief, immune system regulation, growth of cells and angiogenesis (the growth of blood vessels which feed a tumor).

LDN blocks your opioid receptors, as well as the reception of endorphins, for a few hours.  Researchers believe this up-regulates parts of your immune system by increasing your body’s production of metenkephalin and endorphins (your natural opioids), subsequently improving your immune function.

It also inhibits cell proliferation by targeting opioid growth factor (OGF) & opioid growth factor receptor (OGFr) pathways (which regulate the growth of cancer cells).

Lastly, it reduces inflammation in the central nervous system. Glial cells are immune cells which encompass nerve cells.  As signals related to pain become chronic, glial cells are activated and begin to release inflammatory chemicals which trigger nerve cells to become hypersensitized to pain.  LDN works on glial cell receptors and triggers them to become dormant and stop releasing inflammatory chemicals.

• AutoImmune (general)
• Cancer (general)
• Crohn’s Disease
• Depression
• Dissociative Disorder
• Fibromyalgia
• Glioma
• Gulf War Illness

• Adenoid Cystic Carcinoma
• Autism Spectrum Disorder
• AutoImmune (general)
• Bipolar
• Cancer (general)
• Cholangiocarcinoma
• Colon Cancer
• Constipation (chronic)
• Crohn’s Disease
• CRPS
• Darier Disease
• Depression
• Dermatitis Herpetiformis
• Dermatomyositis
• Diabetic Neuropathy
• Erythmodermic Psoriasis
• Esophageal Carcinoma
• Fibromyalgia
• Hailey-Hailey
• Hepatoblastoma
• Hypothyroidism
• IBD
• IBS